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Kamis, 12 Juli 2018

Grand Valley Oncology
src: www.grandvalleyoncology.com

Oncology is a branch of medicine that deals with cancer prevention, diagnosis and treatment. A medical professional practicing oncology is an oncologist . . The etymological origin of his name is the Greek word ????? ( ÃÆ'³nkos ), meaning "tumor", "volume" or "mass" and the word ????? ( logo ), which means "learning".

The three components that have improved cancer survival are:

  1. Prevention - by reducing risk factors such as tobacco and alcohol consumption
  2. Early diagnosis - general cancer screening and comprehensive diagnosis and staging
  3. Treatment - multimodality management with discussions on tumor board and treatment at comprehensive cancer center

Cancer is often managed through discussions at multi-disciplinary cancer conferences in which medical oncologists, surgical oncologists, radiation oncologists, pathologists, radiologists, and certain oncologists meet to find the best management for individual patients who consider physical, social, psychological , emotional, and financial status of patients. It is important for oncologists to keep updating in connection with recent advances in oncology, since changes in cancer management are quite common. All eligible patients in whom the cancer develops, and for whom no standard of care care options are available should be enrolled in clinical trials.


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Risk factors

Tobacco
The main causes of cancer, and deaths from cancer. Smoking is associated with an increased risk of lung, laryngeal, mouth, esophageal, throat, bladder, kidney, liver, stomach, pancreatic, colon, rectal, cervical and acute myeloid leukemia. Tobacco without smoke (tobacco or chewing tobacco) is associated with an increased risk of cancer of the mouth, esophagus, and pancreas.
Alcohol
May increase the risk of cancer of the mouth, throat, esophagus, larynx, liver, and breast. The risk of cancer is much higher for those who drink alcohol and also use tobacco.
Obesity
Obese individuals have an increased risk of breast balloon, colon, rectum, endometrium, esophagus, kidney, pancreas, and gallbladder.
Age
Old age is a risk factor for many cancers. The average age of cancer diagnosis is 66 years.

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Screening

Screening is recommended for breast, cervix, colon and lung cancers.

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Symptoms

Symptoms usually depend on the site and type of cancer.

Breast cancer
Lumps in the breast and axillae associated with or without ulceration or nipple nipple.
Endometrial cancer
Bleeding per vagina.
Cervical Cancer
Bleeding after intercourse.
Ovarian cancer
Nonspecific symptoms such as abdominal distension, dyspepsia.
Lung cancer
Persistent cough, shortness of breath, blood in sputum, hoarseness of voice.
Head and neck cancer
Non-healing or growth ulcers, lumps in the neck.
Brain cancer
Continuous headache, vomiting, loss of consciousness, double vision.
Thyroid cancer
A lump in the neck.
Esophageal cancer
Swallowing the painful especially with solid foods, weight loss.
Stomach cancer
Vomiting, dyspepsia, weight loss.
Colon & amp; rectal cancer
Bleeding per rectum, changes in bowel habits.
Liver cancer
Jaundice, pain and mass in the upper right abdomen.
Pancreatic cancer
Weight, jaundice.
Skin cancer
Non-healing or growth ulcers, moles with a sudden increase in irregular size or border, induration, or pain.
Kidney cancer
Blood in the urine, abdominal bumps.
Cancer of the bladder
Blood in the urine.
Prostate cancer
Urgency, doubt and frequency during urination, bone pain.
Testicular cancer
Testicular swelling, back pain, dyspnoea.
Bone cancer
Pain and bone swelling.
Lymphoma
Fever, weight loss of more than 10% of body weight in the previous 6 months and wet night sweats that are symptoms of B, lumps in the neck, axillae or groin.
Blood cancer
Manifestations of bleeding include bleeding gums, bleeding from the nose, blood in vomit, blood in sputum, blood-stained urine, black stools, fever, lumps in the neck, axillae, or groin, lumps in the upper abdomen.

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Diagnosis and staging

Diagnostic and staging investigations depend on the location and type of malignancy.

Blood cancer

Blood investigations include hemoglobin, total leukocyte count, platelet count, peripheral smear, red blood cell index.

Bone marrow studies include aspiration, Flow-cytometry, Cytogenetics, Fluorescent in situ hybridization and molecular studies.

Lymphoma

Lymph node excision biopsy for Histopathology Examination (HPE), Immuno-histochemistry (IHC) and molecular studies.

Blood supplementation includes lactate dehydrogenase (LDH), Uric Acid Serum, Kidney Function.

Tes pencitraan seperti Computerized Tomography (CT), Positron emission tomography (PET CT).

Bone marrow biopsy.

Solid tumor

Biopsy for histopathology & amp; IHC.

Tes pencitraan seperti Roentgenogram (X-ray), Ultrasonografi, Computerized tomography (CT), Magnetic Resonance Imaging (MRI) dan PET CT.

Endoscopy including Naso-Pharyngoscopy, Direct & amp; Indirect Laringoscopy, Upper Gastrointestinal Endoscopy, Colonoscopy, Cystoscopy.

The tumor markers include alphafetoprotein (AFP), Beta Human Chorionic Gonadotropin (HCG), Carcinoembionic Antigen (CEA), CA 125, prostate specific antigen (PSA).

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Treatment

Treatment depends on the site and type of cancer.

Solid tumor

Breast cancer
Treatment options include surgery, radiation, chemotherapy, hormonal therapy, and targeted therapy (Her 2 neu inhibitors).
Cervical Cancer
Treatment options include radiation, surgery and chemotherapy
Endometrial cancer
Treatment options include surgery, radiation, and chemotherapy.
Ovarian cancer
Treatment options include surgery, chemotherapy, and targeted therapy (VEGF inhibitors).
Lung cancer
Treatment options include surgery, radiation, chemotherapy, and targeted therapy (EGFR & ALK inhibitors).
Head & amp; Cancer of the Neck
Treatment options include surgery, radiation, chemotherapy, and targeted therapy (EGFR inhibitor).
Brain cancer
Treatment options include surgery, radiation, chemotherapy, and targeted therapy (VEGF inhibitors).
Thyroid cancer
Treatment options include surgery and radioactive iodine.
Cancer of the esophagus
Treatment options include radiation, chemotherapy, and surgery.
Stomach cancer
Treatment options include chemotherapy, surgery, radiation, and targeted therapy (Her 2 neu inhibitors).
Colon cancer
Treatment options include surgery, chemotherapy, and targeted therapy (EGFR & VEGF inhibitors).
Rectal cancer
Care options include chemotherapy, radiation, surgery.
Liver cancer
Treatment options include surgery, Trans-arterial chemotherapy (TACE), Abalone Radio Frequency (RFA), and multi-kinase (Sorafenib).
Pancreatic cancer
Treatment options include surgery, radiation, and chemotherapy.
Skin cancer
Treatment options include surgery, radiation, targeted therapy (BRAF & MEK inhibitors), Immunotherapy (CTLA 4 & amp; PD 1 inhibitor, and chemotherapy.) Kidney cancer
Treatment options include surgery, multi-kinase inhibitor, and targeted therapy (mTOR & VEGF inhibitors).
Cancer of the bladder
Treatment options include surgery, radiation, and chemotherapy.
Prostate cancer
Treatment options include surgery, radiation, chemotherapy, anti-androgen, and immunotherapy.
Testicular cancer
Treatment options include surgery, chemotherapy, and radiation.
Bone cancer
Treatment options include surgery, chemotherapy, and radiation.

Lymphoma

These include Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL):

Hodgkin lymphoma (HL)
Chemotherapy with ABVD or BEACOPP regimens and Field radiation therapy Involved (IFRT).
Non-Hodgkin's Lymphoma (NHL)
Chemo-immunotherapy (R-CHOP) for B-cell lymphoma, and chemotherapy (CHOP) for T-cell lymphoma

Blood cancer

Source of the article : Wikipedia

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