FOLFOXIRI is a chemotherapy regimen for the treatment of advanced colorectal cancer. The role of FOLFOXIRI in colorectal cancer has been reviewed.
Chemotherapy regimens consist of the following four medications:
- FOL - folinic acid (leucovorin), a vitamin B derivative that modulates/reduces/adverse effects of fluorouracil;
- F - fluorouracil (5-FU), pyrimidine and antimetabolite analogues that converge into DNA molecules and stop DNA synthesis;
- OX - oxaliplatin (Eloxatin), a platinum-based antineoplastic agent, which inhibits DNA repair and/or DNA synthesis;
- IRI - irinotecan (Camptosar), a topoisomerase inhibitor, which prevents the DNA from curling and doubling.
Usually given with bevacizumab, unlike FOLFIRINOX for the treatment of advanced stage pancreatic cancer. Also, dose (Day 1: irinotecan 165 mg/m2 IV, plus oxaliplatin 85 mg/m2 IV Day 1: leucovorin 400 mg/m2; Day 1-3: fluorouracil 1,600 mg/m2/day ÃÆ'â € "2 days (total 3,200 mg/m2 for 48 hours) continuous infusion starting on the first day, Day 1: bevacizumab 5 mg/kg IV, repeating cycle every 2 weeks) slightly different with FOLFIRINOX.
FOLFOXIRI face with bevacizumab can be followed by fluoropyrimidine with bevacizumab maintenance.
Video FOLFOXIRI
See also
- FOLFIRI
- FOLFOX
- FOLFIRINOX
- IFL
Maps FOLFOXIRI
References
Source of the article : Wikipedia
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