The Children's Oncology Group ( COG ), a clinical trial group supported by the National Cancer Institute (NCI), is the largest organization in the world dedicated to pediatric cancer research. COG conducts a spectrum of clinical research and experimental research trials for infants, children, adolescents, and young adults with cancer.
Nearly all centers treating children with cancer in the US and Canada are part of COG, with more than 200 centers in the United States, Canada, Switzerland, the Netherlands, Australia and New Zealand. Member institutions have a multidisciplinary team of doctors, research scientists, nurses, psychologists, pharmacists and other specialists.
This group, with more than 7,500 experts worldwide, has nearly 100 active clinical-translation trials that are open at any given time. These trials include treatment for many types of cancers in children, research aimed at determining the underlying biology of the disease, and trials involving new and emerging treatments, supportive care, and survival. More than 90% of the 13,500 children and teenagers diagnosed with cancer each year in the United States are admitted to members of the Children's Oncology Group.
Video Children's Oncology Group
History
The cooperative group system for clinical research began in 1955 with a consortium focusing on cancer research in childhood. In the mid-1990s, there were nine groups funded by NCI to conduct research in adults with cancer, and four focused on childhood cancer research. Two groups, the Children's Cancer Study Group (CCG) and Child Oncology Group (POG) studied various cancers in childhood, while two others, the Rhabdomyosarcoma Intergroup Study Group (IRSG) and the National Wilms Tumor Study Group (NWTS) were specific to certain cancers. In 2000, four pediatric groups joined to form the Children's Oncology Group. Since then, researchers have published more than a thousand research papers in peer-reviewed scientific journals. COG has enrolled more children with cancer in clinical trials than any other organization in the world.
Maps Children's Oncology Group
Research study
Group study studies included hematologic malignancies, solid tumors, central nervous system tumors, and rare cancers. Haematological malignancies include the most common childhood cancer, acute lymphoblastic leukemia, and acute myeloid leukemia, non-Hodgkin's lymphoma, and Hodgkin's lymphoma. Solid tumors of children under study include neuroblastoma, bone tumors (Ewing sarcoma, osteosarcoma), renal tumors (Wilms tumor), rhabdomyosarcoma and other soft tissue sarcomas. Central nervous system tumor (brain) is the second most common form of childhood cancer. COG performed research on children with medulloblastoma, ependymoma, glioma brain stem, low and high glioma, and germ cell tumor. The large multi-site structure of COG also makes it possible to conduct research on very rare childhood cancer including retinoblastoma, hepatoblastoma, and other tumors.
In addition to disease-specific research, COG conducts studies in developmental therapies (development of new cancer drugs), supportive care, epidemiology, stem cell transplantation, behavioral sciences and survival.
Funding
COG is primarily funded by NCI, a major grant or Chairman supporting research operations and funding personnel at member institutions conducting research, and statistics and grant data centers supporting these important research functions. Other important grants include the Phase 1 COG Consortium grant, which supports 21 COG bodies charged with early phase clinical trials, and Community Cancer Oncology grant (CCOP) grants. These are additional funds from other grant agencies and from philanthropic sources (cog-foundation.org).
References
External links
- Official website
- COG Foundation
Source of the article : Wikipedia
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